MEDPICKER RX AS A BIOINFORMATICS TOOL

How Does MEDpicker RX Calculate Drug Interactions?

Patients taking several medications often experience medication side effects caused by drug-drug and drug-genotype interactions. Not infrequently,  a patient may not respond to a medication at all.  Most interactions occur at the drug metabolizing enzyme collectively known as Cytochrome peroxidases (CYP) level. These key metabolic enzymes are prone to drug induced modification of their activity, which may substantially alter drug metabolism. Furthermore, genes encoding CYP enzymes are highly mutable, which also alters drug metabolic rates.  While testing for genetic mutations in CYP genes allows to distinguish between slow and rapid metabolizers,  a large number of data points makes it nearly impossible for even a most astute prescriber to promptly and accurately predict drug and genotype interaction effects.

MEDpicker RX is a bioinformatics tool that calculates drug metabolic rate deviations from expected values caused by drug-drug and drug-genotype interactions. Dynamic Medication Selection™ and graphic presentation of drug-gene interaction data helps to find the optimal medication regimen easily and efficiently.

EXAMPLE. A patient is taking the following medications:
Amlodipine
Atorvastatin
Insulin (human)
Metformin
Metoprolol
Tramadol
Warfarin
His genetic analysis indicates that he is:
CYP 2B6 Intermediate metabolizer
CYP 2C9 Intermediate metabolizer
CYP 2D6 Intermediate metabolizer
CYP 3A5 Poor metabolizer
CYP 1A1, 1A2 and 3A4 Extensive metabolizer
If he needed an antidepressant, which antidepressant would you prescribe?

After entering these data into MEDpicker RX, we get the following result shown in the graph below:

Graphic presentation of calculation results  simplifies medication selection for this particular patient. Lower columns correspond to lower probability of side effects. Desvenlafaxine (orange) appears to be a better candidate than Venlafaxine (green) or any SSRIs (1-6 columns on the left).